Osteoprotegerin and Myocardial Fibrosis in Patients with Aortic Stenosis
نویسندگان
چکیده
منابع مشابه
Myocardial extracellular volume fraction and myocardial fibrosis by cmr in patients with severe aortic stenosis
Background Severe aortic stenosis (AS) induces diffuse interstitial myocardial fibrosis (MF). CMR late gadolinium enhancement (LGE) technique is useful to detect focal MF. The amount of MF is associated with worse long-term prognosis after aortic valve replacement surgery (AVR). Measurements of T1 relaxation times before and after gadolinium administration allow determination of myocardial extr...
متن کاملMyocardial Fibrosis and Cardiac Decompensation in Aortic Stenosis
OBJECTIVES Cardiac magnetic resonance (CMR) was used to investigate the extracellular compartment and myocardial fibrosis in patients with aortic stenosis, as well as their association with other measures of left ventricular decompensation and mortality. BACKGROUND Progressive myocardial fibrosis drives the transition from hypertrophy to heart failure in aortic stenosis. Diffuse fibrosis is a...
متن کاملThe Incremental Effect of Obesity on Myocardial Fibrosis In Patients with Aortic Stenosis
There are many studies that show the myocardial fibrosis resulting from hypertension, aortic stenosis or hypertrophic cardiomyopathy, which are under the same condition with chronic pressure overloading. 1-4) Multiple factors are recommended for impaired cardiac function in patients with hyper-tension, such as inflammation, adaptive ventricular remodel-ing, increased mechanical stress inducing ...
متن کاملImpact of myocardial fibrosis in patients with symptomatic severe aortic stenosis.
BACKGROUND In this prospective follow-up study, the effect of myocardial fibrosis on myocardial performance in symptomatic severe aortic stenosis was investigated, and the impact of fibrosis on clinical outcome after aortic valve replacement (AVR) was estimated. METHODS AND RESULTS Fifty-eight consecutive patients with isolated symptomatic severe aortic stenosis underwent extensive baseline c...
متن کاملInfluence of myocardial fibrosis on left ventricular hypertrophy in patients with symptomatic severe aortic stenosis.
AIM It was the aim of our study to determine whether myocardial fibrosis influences physiologic or non-physiologic left ventricular (LV) hypertrophy in severe aortic stenosis. METHODS Myocardial fibrosis was evaluated using specimens taken from the ventricular septum in 79 patients submitted to aortic valve replacement because of symptomatic aortic stenosis. Patients were considered to have p...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2018
ISSN: 2045-2322
DOI: 10.1038/s41598-018-32738-y